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2 edition of Molecular mechanisms of antitumor activity found in the catalog.

Molecular mechanisms of antitumor activity

Working group on molecular mechanisms of carcinogenic and antitumor activity (CittaМЂ del Vaticano 1986)

Molecular mechanisms of antitumor activity

by Working group on molecular mechanisms of carcinogenic and antitumor activity (CittaМЂ del Vaticano 1986)

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  • 14 Currently reading

Published by Pontificia Academia Scientiarum in Città del Vaticano .
Written in English


Edition Notes

Statementedited by Carlos Chagas and Bernard Pullman.
ContributionsChagas, Carlos., Pullman, Bernard, 1919-, Pontificia Academia Scientiarum.
The Physical Object
Pagination489p. :
Number of Pages489
ID Numbers
Open LibraryOL22654646M

The results from short-term tests for genetic and related effects, abstracted from the open literature for 36 anticancer drugs, are examined in this review. Data for 27 of these agents are available in the EPA/IARC Genetic Activity Profile (GAP) database. Data summaries, including data listings and activity profiles, are presented for nine anticancer drugs added to the GAP database for this.   In this review, we summarize the molecular mechanisms of breast cancer organotropic metastasis by focusing on tumor cell molecular alterations, Cited by:

Possible mechanisms underlying the antitumor activity of S-deoxyleinamycin. Sivaramakrishnan, S.; Gates, K. S. Bioorganic Med. Chem. Lett. , 18, DNA strand damage analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for molecular oxygen.   Background: Apricoxib, a selective COX-2 inhibitor, is currently in phase II trials, but its anticancer mechanisms of action could be better defined. Apricoxib inhibits COX-2 enzymatic activity and suppresses production of PGE 2 and VEGF at low nanomolar concentrations but also directly inhibits tumor cell proliferation and survival with μM : F. Burrows.

Antimutagenesis and Anticarcinogenesis Mechanisms II. Editors: Kuroda, Yukioki, Shankel, Delbert M., Molecular Mechanisms of Replicational Fidelity in Escherichia Coli Pages Maki, Hisaji (et al.) Antitumor-Promoting Activity of Sesquiterpene Isolated from an Herbal Spice. Pages Brand: Springer US.   In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. structure-activity relationships in arrhythmias by.


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Molecular mechanisms of antitumor activity by Working group on molecular mechanisms of carcinogenic and antitumor activity (CittaМЂ del Vaticano 1986) Download PDF EPUB FB2

Haji Abdolvahab, H. Schellekens, in International Review of Cell and Molecular Biology, Antitumor Effects. The antitumor activity is mainly mediated by an effect of IFNβ on cell cycle, proliferation, or apoptosis, and indirectly by activation of the immune system (Javed and Reder, ).Its antitumor activity is mediated by three different mechanisms: (1) antiproliferative.

Accordingly, developing new agents within this class is highly valued to help improve the efficacy and overcome intrinsic and acquired drug resistance.

The present study investigated the molecular mechanisms underlying the direct antitumor activity of SB (SB) and provided insights into its novel microtubules inhibitory potential. by:   Molecular mechanisms of the antitumor activity of SB a novel microtubule inhibitor.

Goda AE(1), Koyama M, Sowa Y, Elokely KM, Yoshida T, Kim BY, Sakai T. Author information: (1)Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. [email protected] by: In this review, we focus on the molecular mechanisms of the antitumor activity of taxanes (paclitaxel and docetaxel) in lung cancer, and discuss the interactions of taxanes with microtubules, the roles of cell cycle control and cell death induction in the anticancer action of taxanes, as well as the signal transduction pathways involved in the Cited by: Taxanes are considered fundamental drugs in the treatment of breast cancer, but despite the similarities, docetaxel (doc) and paclitaxel (ptx) work differently.

For this reason, it is interesting to identify mechanisms of antitumor activity of PAMAM dendrimer conjugates that carry docetaxel or paclitaxel and monoclonal antibody trastuzumab, specifically targeted to cells which overexpressed HERAuthor: Monika Marcinkowska, Maciej Stanczyk, Anna Janaszewska, Arkadiusz Gajek, Malgorzata Ksiezak, Paula D.

Title:Molecular Mechanisms Involved in the Antitumor Activity of Isolated Lectins from Marine Molecular mechanisms of antitumor activity book A Systematic Review VOLUME: 21 ISSUE: 6 Author(s):Hugo Jefferson Ferreira, Evandro Moreira de Almeida, Wildson Max Barbosa da Silva, Edson Holanda Teixeira and Luiz Gonzaga do Nascimento Neto* Affiliation:Biomedicine College, Christus University Center, Fortaleza - CE, Biomedicine College Author: Hugo Jefferson Ferreira, Evandro Moreira de Almeida, Wildson Max Barbosa da Silva, Edson Holanda Tei.

Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress. by Paola Massi 1, Marta Valenti 2, Marta Solinas 2 and Daniela Parolaro 2,* 1.

Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via Vanvite Milan, Italy. by: 9. Molecular mechanisms for the antitumor activity of inositol hexakisphosphate (IP6) Article (PDF Available) in Cancer genomics & proteomics 4(1) January with 96 Reads.

The review summarizes literature data on the antitumor activity of niclosamide and its molecular mechanisms. Earlier niclosamide was used for treatment of intestinal parasitic infections. Recent screening of various drugs and chemical compounds, aimed at identifying putative agents with high antitumor activity, revealed that it possesses such by: 1.

Get this from a library. Working Group on Molecular Mechanisms of Carcinogenic and Antitumor Activity, October[Carlos Chagas Filho;]. Working Group on Molecular Mechanisms of Carcinogenic and Antitumor Activity, October Molecular mechanisms of the antitumor effects of anti-CD20 antibodies Article in Frontiers in Bioscience 16(1) January with 21 Reads How we measure 'reads'Author: Magdalena Winiarska.

The molecular mechanism and biological function of autophagy are now basically clear, and Janus role of autophagy determines that it plays an important role in the antitumor process.

Some compounds, plant extracts killing tumor cells through the regulation of autophagy activity, especially induced autophagic cell death has also become an Author: Hai Zhang, Zhinan Chen. P.B. Dervan:in Molecular Mechanisms of Carcinogenesis and Antitumor Activity. Pullman and C.

Chagas Eds. The Vatican Press, distributed by Adenine Press Cited by: Title:Molecular Mechanisms of Biological Activity of Oleanolic Acid - A Source of Inspiration for A New Drugs Design VOLUME: 11 ISSUE: 3 Author(s):Anna Paszel-Jaworska, Aleksandra Romaniuk and Maria Rybczynska Affiliation:Department of Clinical Chemistry, Poznan University of Medical Sciences, Przybyszewskiego Str.

49, Poznan, by: Cancer is the second leading cause of death worldwide. There is always a huge demand for novel anticancer drugs and scientists explore various natural and artificial compounds to overcome this. Gallic acid (GA) is one of the phenolic acids found in many dietary substances and herbs used in ancient medicine.

It possCited by: Steroidal saponins are natural glycosidic compounds of amphiphilic character. Their diverse biological activities are directly related to the variability of their structural constitutive frameworks, aglycones, and sugars. Several studies have demonstrated the therapeutic potential of steroidal saponins by their capacity to induce programmed cell death in different tumor cell by: 1.

The incidence of cancer is increasing in the developed countries and even more so in developing countries parallel to the increase in life expectancy. In recent years, clinicians and researchers advocate the need to include supportive and palliative care since the establishment of the diagnosis and throughout the duration of treatment, with the goal of improving patients' quality of by: I suggest this book to you if you are interested in to study all the tricks of the molecular mechanisms of cancer.

The books is a necessary reading for all medical and biological students interested in Cancer and it will become the reference on the subject.” (Philosophy, Religion and Science Book Reviews, Cited by: Antitumor definition is - preventing or inhibiting the formation or growth of tumors: anticancer.

How to use antitumor in a sentence. The molecular specificities with benzaldehyde and tolbutamide provided fundamental information for understanding the molecular mechanisms involved in the enhancement of in vitro antitumor activity of benzaldehyde in human tumor cell lines and in vivo hypoglycemic effects of tolbutamide in rabbits.

Molecular Mechanisms and their Clinical Application in Malignancies is a collection of manuscripts presented at the 12th Annual Bristol-Myers Squibb Symposium on Cancer Research, held in Toronto, Canada on SeptemberBook Edition: 1.We have designed a new type of tumor-targeted agent by tethering two different drug molecules, with distinct biological mechanisms of action, to the same ligand.

This compound, named EC, represents the “first in class” multidrug, folate receptor (FR)-targeted agent to be disclosed. It was constructed with a single folate molecule, extended by a hydrophilic peptide-based spacer, which Cited by: